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Guide Uterine Leiomyomas: Pathogenesis and Management

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Fibroids: What are Fibroids? Fibroids Symptoms, Treatment, Diagnosis - UCLA

Audit of leiomyoma uterus at Khyber teaching hospital Peshawar. J Ayub Med Coll Abbottabad ; Hutchins FL Jr. Abdominal myomectomy as a treatment for symptomatic uterine fibroids. Obstet Gynecol Clin North Am ; Hysterectomy: A clinico-pathological correlation of cases. Internet J Gynecol Obstet ; Te Linds's Operative Gynaecology. Hysterectomy: The patient's perspective. Ann Gynecol ; Gupta S, Manyonda I. Hysterectomy for benign gynaecological diseases. Curr Obstet Gynaecol ; Rani SV, Thomas S. Leiomyoma, a major cause of abnormal uterine bleeding. J Evol Med Dent Sci ; Ashraf T.

The Role of Fibroblast Activation in Uterine Fibroid

Management of uterine leiomyomas. J Coll Physicians Surg Pak ; Fibroid as a causative factor in menorrhagia and its management. J Med Res ; Derek LJ. Benign enlargement of uterus. In: Fundamentals of Obstetrics and Gynaecology. London: Mosby; Jaiswal CJ.

Vaginal management of uterocervical myomas. J Obstet Gynecol India ; Abraham R. Uterine fibroids. In: Manual of clinical problems in Obstet Gynaecol. Rosario YP. Uterine leiomyomas. J Obstet Gynecol India ; Chhabra S, Ohri N. Leiomyomas of uterus — A clinical study. Persaud V, Arjoon PD. Uterine leiomyoma. In the postpartum period, women with fibroids have an increased risk of postpartum hemorrhage secondary to an increased risk of uterine atony. The evaluation of fibroids is based mainly on the patient's presenting symptoms: abnormal menstrual bleeding, bulk symptoms, pelvic pain, or findings suggestive of anemia.

Fibroids are sometimes found in asymptomatic women during routine pelvic examination or incidentally during imaging.

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Table 2 includes the differential diagnosis of uterine masses. Uterine sarcoma leiomyosarcoma, endometrial stromal sarcoma, mixed mesodermal tumor. Information from reference The ideal treatment satisfies four goals: relief of signs and symptoms, sustained reduction of the size of fibroids, maintenance of fertility if desired , and avoidance of harm.

Figure 1 presents an algorithm for the management of uterine fibroids. Gonadotropin-releasing hormone agonists Preoperative treatment to decrease size of tumors before surgery or in women approaching menopause. Long-term treatment associated with higher cost, menopausal symptoms, and bone loss; increased recurrence risk with myomectomy.


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Levonorgestrel-releasing intrauterine system Mirena Most effective medical treatment for reducing blood loss; decreases fibroid volume. Nonsteroidal anti-inflammatory drugs Oral contraceptives Reduce blood loss from fibroids; ease of conversion to alternate therapy if not successful. Selective progesterone receptor modulators 35 , Decrease blood loss, operative time, and recovery time; not associated with hypoestrogenic adverse effects. Headache and breast tenderness, progesterone receptor modulator—associated endometrial changes; increased recurrence risk with myomectomy.

Tranexamic acid Cyklokapron 37 , Surgical removal of the uterus transabdominally, transvaginally, or laparoscopically. Definitive treatment for women who do not wish to preserve fertility; transvaginal and laparoscopic approach associated with decreased pain, blood loss, and recovery time compared with transabdominal surgery.

Surgical risks higher with transabdominal surgery e. Magnetic resonance—guided focused ultrasound surgery Uterine artery embolization Information from references 32 through Clinical surveillance 4.


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Infertile women with distorted uterine cavity i. Medical treatment or myomectomy 34 , 38 , Symptomatic women who do not desire future fertility but wish to preserve the uterus. Medical treatment, myomectomy, uterine artery embolization, magnetic resonance—guided focused ultrasound surgery 34 , 38 , 40 — Symptomatic women who want definitive treatment and do not desire future fertility.

Hysterectomy by least invasive approach possible 43 , Information from references 4 , 16 , 34 , 38 , and 40 through The management of uterine leiomyomas. J Obstet Gynaecol Can. Because there is minimal concern for malignancy in women with asymptomatic fibroids, watchful waiting is preferred - for management.


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  • Uterine Fibroids : Understanding their Origins to Better Understand their Future Treatments.

Hormonal Contraceptives. Women who use combined oral contraceptives have significantly less self-reported menstrual blood loss after 12 months compared with placebo.

Tranexamic Acid. Nonsteroidal Anti-inflammatory Drugs. Another medical option for the treatment of uterine fibroids is a non-steroidal anti-inflammatory drug. Hormone Therapy. Gonadotropin-releasing hormone GnRH agonists and selective progesterone receptor modulators SPRMs are options for patients who need temporary relief from symptoms preoperatively or who are approaching menopause.

Preoperative administration of GnRH agonists e. The most common adverse effects include headache and breast tenderness. The advantage of SPRMs over GnRH agonists for preoperative adjuvant therapy is their lack of hypoestrogenic adverse effects and bone loss. However, SPRMs can result in progesterone receptor modulator—associated endometrial changes, although these seem to be benign.

Other Agents. Other, less-studied options for the treatment of uterine fibroids include aromatase inhibitors and estrogen receptor antagonists. Aromatase inhibitors e. Limited data have shown that they help reduce fibroid size as well as decrease menstrual bleeding, with adverse effects including hot flashes, vaginal dryness, and musculoskeletal pain. Another selective estrogen receptor modulator, raloxifene Evista , has also shown inconsistent results, with two of three studies included in a Cochrane review showing significant benefit. Hysterectomy provides a definitive cure for women with symptomatic fibroids who do not wish to preserve fertility, resulting in complete resolution of symptoms and improved quality of life.

Hysterectomy by the least invasive approach possible is the most effective treatment for symptomatic uterine fibroids. The laparoscopic extraction of the uterus may be performed with morcellation, whereby a rotating blade cuts the tissue into small pieces. This technique has come under scrutiny because of concerns about iatrogenic dissemination of benign and malignant tissue. The U. Food and Drug Administration recommends limiting the use of laparoscopic morcellation to reproductive-aged women who are not candidates for en bloc uterine resection.

Hysteroscopic myomectomy is the preferred surgical procedure for women with submucosal fibroids who wish to preserve their uterus or fertility. Uterine Artery Embolization. Uterine artery embolization is an option for women who wish to preserve their uterus or avoid surgery because of medical comorbidities or personal preference.

The most common complication is postembolization syndrome, which is characterized by mild fever and pain, and vaginal expulsion of fibroids. There is insufficient evidence on the effect of uterine artery embolization on future fertility. An observational study of 26 women treated with uterine artery embolization and 40 treated with hysterectomy found no difference in live birth rates. Further studies are needed on fertility outcomes after uterine artery embolization so that patients can be counseled appropriately.

Myolysis is a minimally invasive procedure targeting the destruction of fibroids via a focused energy delivery system such as heat, laser, or more recently, magnetic resonance—guided focused ultrasound surgery MRgFUS. This article updates a previous article on this topic by Evans and Brunsell.

Pathogenesis, Classification, Histopathology, and Symptomatology of Fibroids

Data Sources: A PubMed search was completed in Clinical Queries using the key terms leiomyoma, uterine fibroids, diagnosis, management, power morcellation, and guidelines. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Search date: October 25, Already a member or subscriber? Log in. Address correspondence to Maria Syl D. Reprints are not available from the authors.